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A collection of genes utilized by the RNA interference (RNAi) pathway; the RNAi pathway is a biological process in which RNA molecules inhibit gene expression or translation by neutralizing targeted mRNA molecules. Ideal for genetic screening.
An inhibitor of microtubule assembly cytotoxic to a variety of cancer cells including SKOV3 ovarian U87 glioblastoma and AsPC-1 pancreatic cancer cells (IC50s 36 77 and 285 nM respectively) induces complete tumor regression in a rat Yoshida AH13 sarcoma model at 10 mg/kg without inducing systemic or neurotoxicity
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